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Abbreviations: TCAs tricyclic antidepressants TeCAs tetracyclic antidepressants SARIs serotonin antagonist and reuptake inhibitors MAOIs monoamine oxidase inhibitors SSRIs selective serotonin reuptake inhibitors SNRIs serotonin and norepinephrine reuptake inhibitors NDRI norepinephrine–dopamine reuptake inhibitors RM reactive metabolite ROS reactive oxygen species DDI drug-drug interactions DILI drug induced liver injury HLM human liver microsomes MLM mouse liver microsomes RLM rat liver microsomes LC-MS liquid chromatography mass spectrometry P450 cytochrome P450 GSH glutathione GSH-EE glutathione ethyl ester KCN potassium cyanide NAc N-acetylcysteine COMT catechol- O -methyltransferase NADPH nicotinamide adenine dinucleotide phosphate, reduced HRP horse radish peroxidase AO aldehyde oxidase CNS central nervous system MAO monoamine oxidase LSD lysine specific demethylase FAD flavin adenine dinucleotide MDD major depressive disorder ADHD attention-deficit hyperactivity disorder Footnotes Conflict of interest None References (2012a) Milnacipran, in: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda (MD)
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Moreover, two main types of receptor-mediated mitophagy pathway have been classified as follows in brief: ubiquitin-independent mitophagy receptors, including BCL2-interacting protein 3 (BNIP3) (Quinsay et al., 2010), BCL2-interacting protein 3 like (NIX/BNIP3L) (Sandoval et al., 2008), FUN14 domain-containing 1 (FUNDC1) (Liu et al., 2012), BCL2-like 13 (BCL2L13) (Otsu et al., 2015), autophagy and beclin 1 regulator 1 (AMBRA1) (Strappazzon et al., 2015), FKBP prolyl isomerase 8 (FKBP8) (Wei et al., 2017), and NLR family member X1 (NLRX1) (Zhang et al., 2019)
