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Nucleic acid delivery vectors The ideal nucleic acid delivery system should be safe and well-tolerated, capable of overcoming extracellular and intracellular barriers, resistant to nucleases in the bloodstream, possess specific tumor-targeting ability with low off-target effects, have broad gene insertion capacity and high transfection efficiency, allow sustained gene expression, and promote endosomal escape of nucleic acid drugs upon entry into cells [47, 48]