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Visible Light-Responsive Dynamic Biomaterials: Going Deeper and Triggering More

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Studies of the crystal structure of T4 endonuclease V in complex with cyclobutane pyrimidine dimer (CPD) DNA showed that the enzyme kinks the DNA duplex and flips out the complementary adenine base in the opposite strand out of the DNA base stack, thus avoiding accommodation of bulky CPD within the protein surface (Vassylyev et al., 1995) (Figures 3C,D,F)