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Compared with that in neutrophils from healthy volunteers, the expression of GLUT-3 and GLUT-6 is reported to be decreased in the cell membranes of neutrophils from patients with SLE, along with a concomitant decrease in intracellular glucose concentration ( Similarly, single-cell RNA sequencing analysis of metabolism-related genes revealed decreased glycolysis and TCA cycling but increased OXPHOS in lupus nephritis renal epithelial clusters ( Conversely, activated glycolysis regulates the functions of T cells involved in SLE pathogenesis
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Results Cystine availability regulates mTORC1 signaling and the ISR We studied the effect of cystine starvation in HepG2 cells, which do not synthesize cysteine from methionine, to exclude the confounding effect of methionine 20
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