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doi: 10.3389/fimmu.2024.1337208 Received 12 November 2023 Accepted 24 April 2024 Published 10 May 2024 Volume 15 - 2024 Edited by Undurti Narasimha Das, UND Life Sciences LLC, United States Reviewed by Marco De Andrea, University of Turin, Italy Aikaterini Alexaki, Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland Updates Copyright © 2024 Zhang, Zhao, Zhang, Wu, Li, Yang, Zhang, Wei, Xi, Zhou, Wang, Du, Huang, Ge and Lu
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[,] The increased plasma 14,15-EET rapidly cross the blood–brain barrier, activate the protective effects of astrocytes in the cortex (including mPFC), and prevent cerebral amyloid-β (Aβ) deposition by modulating Aβ metabolism, thus mediating the neuroprotective effects of hepatic sEH ablation