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It was approved by the Russian Ministry of Health in 1994 for cerebrovascular indications and has been used in Russian clinical settings for ischemic stroke, cognitive decline, and optic nerve disorders for more than three decades

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Shibuya et al., 2009) and non-CG methylation (Inoue and Oishi, 2005) could have a biological relevance, single-base analysis of genome-wide DNA methylation is of critical importance