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Natural compounds such as curcumin, resveratrol, sulforaphane, and propolis exhibit strong anti-inflammatory and antioxidative properties by modulating redox-sensitive pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase (HO-1)

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These findings also support our observation that BoNT/X protease causes toxicity in HEK293T cells, likely due to cleavage of additional, unidentified substrates (Supplementary Fig