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While failure of these compensatory mechanisms could ultimately cause ferroptotic cell death, more subtle changes in intracellular redox balance could also enhance signaling pathways, including those associated with T2 inflammation (10)

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406,407 Detailed analysis of astrocytic morphology using genetic reports (either ALDH1L1-eGFP reporter mice or viral transfection with astrocyte-targeted mCherry) revealed significant decrease of astrocytic complexity and shrinkage of astrocytic territorial domains in prefrontal cortex (Fig