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Keywords: G6PD deficiency, athlete, international, medication safety, supplements Science and Clinical Presentation of G6pd Deficiency In an unaffected human, glucose-6-phosphate dehydrogenase (G6PD) plays a key role in protecting red blood cells from oxidative injury by catalyzing the reduction of NADP+ (nicotinamide adenine dinucleotide phosphate) to NADPH (reduced form of NADP+) via the pentose phosphate pathway (Figure 1)