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Keywords: acute kidney injury (AKI), fibrosis, chronic kidney disease (CKD), oxidative stress, end-stage renal disease (ESRD), myofibroblast, cell signaling Graphical Abstract Schematic presentation of target genes and signaling pathways associated with ROS-induced initial stage of AKI, its transition to intermediate stage of kidney fibrosis, and finally its progression to CKD

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8 Therapy of tendon injury 8.1 Antioxidants in tendon injury and repair Pharmacological antioxidant therapy has emerged as a promising approach for modulating oxidative stress in tendon injuries, aiming to counteract the deleterious effects of excessive ROS on tendon cells and ECM integrity