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124 Di- and triquinanes containing cyclopentenones have shown antiproliferative activity with IC 50 values between 0.11-5.7 μM in cancer cell lines (P388, L1210, 3LL, and LY cells), with representative compound 333 shown to form adducts 334-335 with cysteine and propanethiol in good yields (Scheme 20)

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