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In vitro studies demonstrated that glutamine supplementation decreased the production of pro-inflammatory cytokines IL-6, IL-8, and/or TNFα, while increasing the production of anti-inflammatory/regulatory cytokine IL-10 in various activated adult human immune cells, including intra-epithelial lymphocytes (IELs), intestinal mast cells, peripheral mononuclear cells (PBMCs) and monocytes (162–165)