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Research shows that the metabolic characteristics of ccRCC are also closely linked to the host’s systemic metabolic status (such as obesity-related lipid mobilisation and diabetes-related hyperglycaemia) ( 5.2 Toxicity management and activation of metabolic adaptive bypass pathways Metabolic reprogramming enables tumor cells to survive in harsh environments and may also improve treatment tolerance

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In the original study, FOXO4-DRI showed 11.73-fold selectivity for senescent versus non-senescent human fibroblasts