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However, one could argue that the direct effect of fumarate on the activity of the potent tumor suppressor PTEN [51] suggests a possible role as a cancer initiator

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While alterations in SGCC rCBF and ESC/E(Z) gene expression could be independent events, it is possible that altered expression of ESC/E(Z) complex genes in the SGCC directly impacts SGCC neurophysiology and, therefore, contributes to the ovarian steroid-induced alterations in rCBF we observed in PMDD