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Metabolic adaptation of the cellular component of the BM niche induces a HIF1α-dependent glycolytic program, which increases CD73 and ADOR expression ( + ) (Figure 1, after consuming glucose at a higher rate than normal cells, MM cells secreted most of the derived byproducts as lactic acid, a phenomenon known as the “Warburg Effect” ( + ) results in acid accumulation within MM cells

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However, in patients with a non-dipping pattern at baseline, the proportion of dippers for systolic/diastolic BP at 8 weeks of follow-up (36.5% vs