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NADPH is a substrate/cofactor for several enzymes involved in the cellular antioxidant defense, including glutathione reductase (GSH regeneration), peroxiredoxins and thioredoxin, as well as for several detoxifying systems (Pollak et al., + ratio contributing to oxidative stress and reducing the cellular ability to recover after an oxidative insult (Pollak et al., Interaction of AKR1B1 with drugs AKR1B1 is an important drug target due to its implication in the development of diabetic complications

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