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Each mechanism discussed in this review is proposed to cause insulin resistance by either increasing nutrient-derived toxic metabolites (DAG, ceramide, acylcarnitine, BCAA), overdriving nutrient utilization processes (ER stress, oxidative stress), or responding to nutrient stress-mediated cellular toxicity (inflammation)
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The test is recorded on video to analyze the frequency of entries into each arm and the duration spent in the novel arm (the arm that was initially closed)
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