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Research illuminates that sodium propionate (SP)—a distinguished SCFA representative—when administered via encapsulated formulations to maintenance hemodialysis patients, orchestrates immune-metabolic equilibrium through multidimensional pathways: it significantly attenuates pro-inflammatory parameters including CRP, IL-1, and IL-17, while simultaneously upregulating anti-inflammatory mediators such as IL-10, concurrently reducing gut-derived uremic toxin production (IS and PCS), neutralizing oxidative stress markers including malondialdehyde, and rebalancing insulin resistance and iron metabolism perturbations (Marzocco et al., 2018)