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An early study co-administered the typical antipsychotic chlorpromazine (50 mg p.o), which antagonizes both D 2 and 5HT 2A receptors, with psilocybin (0.2 mg/kg p.o.), resulting in attenuation in psilocybin-induced mydriasis and visual perceptual changes (Keeler 1967).Vollenweider et al

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This appetite effect is driven by GHRP-6’s strong activation of ghrelin-mediated feeding circuits in the hypothalamic arcuate nucleus — the same pathway that endogenous ghrelin uses to signal hunger