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Strikingly, two reports demonstrated MAOI efficacy as both a monotherapy and combination therapy with anti-PD-1 in the typically responsive colon cancer MC38, as well as in B16 melanoma cells, which have historically been less responsive to immunotherapy ( Possible Issues with MAOIs for ICB Therapy While MAOIs were the primary class of antidepressants for the majority of the second half of the 20th century, they have fallen largely out of fashion due to the adverse side effects associated with their administration and the rise of alternative drugs ( Figure 1B ) ( Despite these potential negatives, the utilization of MAOIs still shows significant promise, and the process should be optimized to increase drug efficacy and patient wellbeing