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Induction of renal and pancreatic injuries by cyclosporine (15 mg/kg/day) in rats was treated by l-carnitine (50 or 200 mg/kg/day) for a month, the result of which was inhibition of LC3-II and caspase-3 expression, suppression of 8-OHdG and TGF-β1 expression, improved inflammation and renal function, decreased HbA1c and plasma glucose levels, and elevated plasma insulin level [80]

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HRT hormone replacement therapy IHC immunohistochemistry iod integrated optical density IPA Ingenuity Pathway Analysis iTRAQ isobaric tag for relative and absolute quantitation KEGG Kyoto Encyclopedia of Genes and Genomes LC liquid chromatography MDA malondialdehyde MRM multiple reaction monitoring MS mass spectrometry OVX ovariectomized PBS phosphate-buffered saline PLS partial least squares regression analysis qRT-PCR quantitative reverse transcriptase polymerase chain reaction SOD superoxide dismutase TBS-T triethanolamine-buffered saline solution containing Tween TOF time of flight UA uric acid WB western blot References 1 AhmedS